The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat
1994; Elsevier BV; Volume: 4; Issue: 4 Linguagem: Inglês
10.1016/0924-977x(94)90293-3
ISSN1873-7862
AutoresJaime M. Monti, Héctor Jantos, Christian Leschke, Sigurd Elz, Walter Schunack,
Tópico(s)Olfactory and Sensory Function Studies
ResumoThe effects of the selective histamine H1-receptor agonist, 2-(3-trifluoromethylphenyl)histamine, were studied in rats implanted with electrodes for chronic sleep recordings. 2-(3-Trifluoromethylphenyl)histamine (80-120 micrograms) injected into the left lateral ventricle increased wakefulness, whereas slow wave sleep was reduced. Pretreatment with pyrilamine (2.0 mg/kg) prevented the effects of the H1-receptor agonist on wakefulness and slow wave sleep. Our results further support the involvement of histamine in the modulation of the waking state.
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