Differential response in the release of hydrogen peroxide between astroglial cells and endothelial cells following hypoxia/reoxygenation
1996; Elsevier BV; Volume: 215; Issue: 2 Linguagem: Inglês
10.1016/0304-3940(96)12954-2
ISSN1872-7972
AutoresTakeo Kondo, Hiroyuki Kinouchi, Makoto Kawase, Takashi Yoshimoto,
Tópico(s)Neonatal and fetal brain pathology
ResumoHydrogen peroxide (H2O2) and lactate dehydrogenase (LDH) released from cultured astroglial cells (AGs) and brain endothelial cells (BECs) were measured following hypoxia/reoxygenation. AGs released H2O2 to the extracellular space from 8 h of hypoxia with the cellular injury indicated by LDH increase. In contrast, BECs released H2O2 at 4 h of hypoxia, prior to the LDH increase. These results suggest that AGs and BECs play different roles in production and metabolism of oxygen free radicals in the blood-brain barrier (BBB), and AGs may protect the BBB disruption from oxidative stress after hypoxia/reoxygenation.
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