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Breakdown of cartilage proteinpolysaccharide by lysosomes

1968; Wiley; Volume: 11; Issue: 2 Linguagem: Inglês

10.1002/art.1780110206

1529-0131

Gerald Weissmann, Isaias Spilberg,

Carbohydrate Chemistry and Synthesis

Arthritis & RheumatismVolume 11, Issue 2 p. 162-169 ArticleFree to Read Breakdown of cartilage proteinpolysaccharide by lysosomes Gerald Weissmann MD, Gerald Weissmann MD Associate Professor of Medicine, New York University; Career Research Scientist of the Health Research Council of New York City (1–467). Medicine and The Study Group for Rheumatic Diseases of the New York University School of Medicine.Search for more papers by this authorIsaias Spilberg, Isaias Spilberg Trainee, Study Group for Rheumatic Diesases, New York University. Medicine and The Study Group for Rheumatic Diseases of the New York University School of Medicine.Search for more papers by this author Gerald Weissmann MD, Gerald Weissmann MD Associate Professor of Medicine, New York University; Career Research Scientist of the Health Research Council of New York City (1–467). Medicine and The Study Group for Rheumatic Diseases of the New York University School of Medicine.Search for more papers by this authorIsaias Spilberg, Isaias Spilberg Trainee, Study Group for Rheumatic Diesases, New York University. Medicine and The Study Group for Rheumatic Diseases of the New York University School of Medicine.Search for more papers by this author First published: April 1968 https://doi.org/10.1002/art.1780110206Citations: 78AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Hunter, W.: Of the structure and diseases of articulating cartilages. Philosoph. Trans. Royal Soc. 42: 514, 1743. 2 Phemister, D. B.: The effect of pressure on articular surfaces in pyogenic and tuberculous arthritides and its bearing on treatment. Ann. Surg. 80: 481, 1924. 3 Curtiss, P. H., and Klein, L.: Destruction of articular cartilage in septic arthritis I. In Vitro studies. J. Bone Joint Surg. 45: 797, 1963. 4 Potter, J. L., McCluskey, R. T., Weissmann, G., and Thomas, L.: The removal of cartilage matrix by papain. Factors affecting the distribution of crystalline papain in vivo. J. Exp. Med. 112: 1173, 1960. 5 Thomas, L., McCluskey, R. T., Potter, J. L., and Weissmann, G.: Comparison of the effects of papain and vitamin A on cartilage. I. The effects in rabbits. J. Exp. Med. 111: 705, 1960. 6 Dingle, J. T.: Action of vitamin A on the stability of lysosomes in vivo and in vitro. In A. V. S. de Reuck, and M. P. Cameron (Eds.): Ciba Foundation Symposium on Lysosomes. Boston, Little, Brown Co., 1963, p. 384. 7 Ziff, M., Gribetz, H. J., Lospalluto, J.: Effect of leukocyte and synovial membrane extracts on cartilage mucoprotein. J. Clin. Invest. 39: 405, 1960. 8 Ali, S. Y.: The degradation of cartilage matrix by an intracellular protease. Biochem. J. 93: 611, 1964. 9 Fell, H. B., and Dingle, J. T.: Studies on the mode of action of excess of vitamin A. 6. Lysosomal protease and the degradation of cartilage matrix. Biochem. J. 87: 403, 1962. 10 Barrett, A. J.: Chondromucoprotein-degrading enzymes. Nature 211: 1188, 1966. 11 Weissmann, G., and Uhr, J. W.: Studies on lysosomes. IX. Localization of bacteriophages, thorotrast, and inflammatory properties. Biochem. Pharmacol. (in press). 12 Pal, S., Doganges, P. T., and Schubert, M.: The separation of new forms of the protein polysaccharides of bovine nasal cartilage. J. Biol. Chem. 241: 4261, 1966. 13 Weissmann, G.: Lysosomes and joint disease. Arthritis Rheum. 9: 834, 1966. 14 Zvaifler, N.: A speculation on the pathogenesis of joint inflammation in rheumatoid arthritis. Arthritis Rheum. 8: 289, 1965. 15 Gerber, B. R., and Schubert, M.: The exclusion of large solutes by cartilage proteinpolysaccharide. Biopolymers 2: 259, 1964. 16 Cohn, Z. A., and Hirsch, J. G.: Isolation and properties of specific cytoplasmic granules of rabbit polymorphonuclear leukocytes. J. Exp. Med. 112: 983, 1960. 17 Weissmann, G., Becher, B., and Thomas, L.: Studies on lysosomes. V. The effects of streptolysins and other hemolytic agents on isolated leucocyte granules. J. Cell. Biol. 22: 115, 1964. 18 Ashwell, G.: Colorimetric analysis of sugars. In S. P. Colowick, and N. O. Kaplan (Eds.): Methods in Enzymology, Vol. III, New York, Academic Press, 1957, p. 80. 19 Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265, 1951. 20 Weissmann, G., Potter, J. L., McCluskey, R. T., and Schubert, M.: Turbidity produced by hexamminecobaltic chloride in serum of rabbits injected intravenously with papain. Proc. Soc. Exp. Biol. Med. 102: 584, 1959. 21 Alkjaersig, N., Fletcher, A. P., and Sherry, S.: Epsilon-amino-caproic acid: an inhibitor of plasminogen activation. J. Biol. Chem. 234: 832, 1959. 22 Aronson, N. B., Jr., and Davidson, E. A.: Lysosomal hyaluronidase. J. Biol. Chem. 240: 1322, 1965. 23 Mounter, L. A., and Atiyeh, W.: Proteases of human leukocytes. Blood 15: 52, 1960. 24 Lack, C. M., and Ali, S. Y.: Tissue activator of plasminogen. Nature 201: 1031, 1964. 25 Dingle, J. T., Fell, H. B., and Coombs, R. R. A.: The breakdown of embryonic cartilage and bone cultivated in the presence of complement-sufficient antiserum. II. Biochemical changes and the role of the lysosomal system. Int. Arch. Allergy. 31: 283, 1967. 26 Bollett, A. J., Bonner, W. M., Jr., and Nance, J. L.: The presence of hyaluronidase in various mammalian tissues. J. Biol. Chem. 238: 3522, 1963. 27 Luscombe, M.: Acid phosphatase and catheptic activity in rheumatoid synovial tissue. Nature. 197: 1010, 1963. 28 Bowers, W. E., and de Duve, C.: Lysosomes in lymphoid tissue. II. Intracellular distribution of acid hydrolases. J. Cell Biol. 32: 339, 1967. Citing Literature Volume11, Issue2April 1968Pages 162-169 ReferencesRelatedInformation