A simple and eco-friendly approach for the synthesis of 2-imino and 2-oxo-2H-chromene-3-carboxamides
2008; Royal Society of Chemistry; Volume: 10; Issue: 9 Linguagem: Inglês
10.1039/b807892k
ISSN1463-9270
AutoresM. Fernanda R. P. Proença, Marta Costa,
Tópico(s)Synthesis and biological activity
ResumoA series of new 2-imino-2H-chromene-3-carboxamides 5 were synthesized in excellent yield and high atom economy by the Knoevenagel condensation of salicylaldehyde derivatives 4 and N-substituted cyanoacetamides 3 using aqueous sodium carbonate or hydrogen carbonate solution, at room temperature. Treatment of compounds 5 with aqueous HCl led to the formation of the corresponding 2-oxochromenes 6.
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