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Dendritic Folate Rosettes as Ion Channels in Lipid Bilayers

2006; American Chemical Society; Volume: 128; Issue: 7 Linguagem: Inglês

10.1021/ja058157k

1943-2984

Naomi Sakai, Yuko Kamikawa, Masayuki Nishii, Toru Matsuoka, Takashi Kato, Stefan Matile,

Molecular Sensors and Ion Detection

The self-assembly of folate dendrimers into pi-stacked supramolecular rosettes is shown to produce ion channels in planar and spherical lipid bilayer membranes. The found ion channels are small, quite homogeneous, long-lived, ohmic, cation selective (Eisenman I), and blockable by the permeant cation.