Revisão Acesso aberto Revisado por pares

Allergen‐specific IgG4 in atopic disease

1993; Wiley; Volume: 48; Issue: 8 Linguagem: Inglês

10.1111/j.1398-9995.1993.tb00749.x

ISSN

1398-9995

Autores

R.C. Aalberse, F. Van Milligen, K. Y. Tan, Steven O. Stapel,

Tópico(s)

Asthma and respiratory diseases

Resumo

AllergyVolume 48, Issue 8 p. 559-569 Free Access Allergen-specific IgG4 in atopic disease R. C. Aalberse, Corresponding Author R. C. Aalberse Publication Secretariat, CLB, Amsterdam, The NetherlandsProf. Dr R. C. Aalberse, P/0 Publication Secretariat, CLB, PO Box 9406, 1006 AK Amsterdam, The NetherlandsSearch for more papers by this authorF. Van Milligen, F. Van Milligen Publication Secretariat, CLB, Amsterdam, The NetherlandsSearch for more papers by this authorK.Y. Tan, K.Y. Tan Department of Allergy, Holy Hospital, Rotterdam, The NetherlandsSearch for more papers by this authorS.O. Stapel, S.O. Stapel Publication Secretariat, CLB, Amsterdam, The NetherlandsSearch for more papers by this author R. C. Aalberse, Corresponding Author R. C. Aalberse Publication Secretariat, CLB, Amsterdam, The NetherlandsProf. Dr R. C. Aalberse, P/0 Publication Secretariat, CLB, PO Box 9406, 1006 AK Amsterdam, The NetherlandsSearch for more papers by this authorF. Van Milligen, F. Van Milligen Publication Secretariat, CLB, Amsterdam, The NetherlandsSearch for more papers by this authorK.Y. Tan, K.Y. Tan Department of Allergy, Holy Hospital, Rotterdam, The NetherlandsSearch for more papers by this authorS.O. Stapel, S.O. Stapel Publication Secretariat, CLB, Amsterdam, The NetherlandsSearch for more papers by this author First published: November 1993 https://doi.org/10.1111/j.1398-9995.1993.tb00749.xCitations: 123AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Aalberse RC. The use of radioimmunoassay procedures for the detection of IgG antibodies to allergens. In: M Ricci, AS Fatjcl, P Arcangeli, P Torzuoli, eds. Developments in clinical immunology. London : Academic Press, 1978: 149–60. 2 Aalberse RC. IgG subclasses in atopic eczema. In: T Ruzicka, J Ring, B Przybilla, eds. Handbook of atopic eczema. Berlin : Springer-Verlag, 1991: 166–72. 3 Aalberse RC, Dieges PH, Knul-Bretlova V, Vooren P, Aalbers M, Van Leeuwen J. IgG4 as a blocking antibody. In: GM Halpern, ed. Clinical reviews in allergy. Vol. 1. New York : Elsevier, 1983: 289–302. 4 Aalbersb RC, Reerink-Brongers EE, Vermeulen E. RAST-inhibiting factors in human serum, Int Arch Allergy Appl Immunol 1973: 45: 46–9. 5 Aalberse RC, Reerink-Brongers EE, Hoorweg E. Methods for the assay of allergen-neutralizing antibodies based on competition with IgE antibodies for allergen. In: H Peeters, ed. Praotides of the biological fluids. 24th Colloquium. Oxford : Pergamon Press, 1976: 725–9. 6 Aalberse RC, van der Gaag R, van Leeuwen J. Serologic aspects of lgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. J Immunol 1983: 130: 722–6. 7 Aalberse RC, van der Zee JS, Vlug A. IgG4 antibodies in atopic allergy. Lab Manage 1985: 23: 19–32. 8 Alber G, Kent UM, Metzgbr H. Functional comparison of FCαRI, FcgammaRII, and FcgammaRIII in mast cells. J Immunol 1992: 149: 2428–36. 9 Anselmino LM, Perussia B, Thomas LL. Human basophils selectively express the Fc gamma RII (CDw32) subtype of IgG receptor. J Allergy Clin Immunol 1989: 84: 907–14. 10 Barnes RMR, Johnson PM, Blears J, Harvey MM, Finn R. Human serum antibodies reactive with dietary proteins. Antigenic specificity. Int Arch Allergy Appl Immunol 188: 87: 189–93. 11 Barnes RMR, Johnson PM, Harvey MM, Blears J, Finn R. Human serum antibodies reactive with dietary proteins. IgG subclass distribution. Int Arch Allergy Appl Immunol 1988: 87: 184–8. 12 Beauvais F, Hieblot C, Burtin C, Benveniste J. Bimodal lgG4-mediated human basophil activation: role of eosinophils. J Immunol 1990: 14: 3881–90. 13 Binaghi RA. Nonreaginic anaphylactie antibodies in animals. In: GM Halpern, ed. Nonreaginic anaphylactic and/or blocking antibodies. Clinical reviews in allergy. Vol. 1, No. 2. New York : Elsevier, 1983: 237–47. 14 Brighton WD. Frequency of occurrence of IgG(S-TS). Clin Allergy 1980: 10: 97–100. 15 Calkhoven PG. The role of food antigens in the development of inhalant allergy. Thesis, University of Amsterdam, Meppel : Krips Repro, 1989: 1–114. 16 Calkhoven PG, Aalbers M, Koshte VL, POS O, Oei HD, Aalberse RC. Cross-reactivity among birch pollen, vegetables and fruits as detected by IgE antibodies is due to at least three distinct cross-reactive structures. Allergy 1987: 42: 382–90. 17 Carini C, Fratazzi C. Detection of IgG subclasses with anti-IgE activity in patients with atopic diseases. Int Arch Allergy Appl Immunol 1992: 98: 227–32. 18 Chapman MD, Platts-Mills TAE. Measurement of IgG, IgA and IgE antibodies to Dermatophagoides pteronyssinus by antigen-binding assay, using a partially purified fraction of mite extract (F4P1). Clin Exp Immunol 1978: 34: 126–36. 19 Chapman MD, Rowntree S, Mitchell EB, DI Prisco DE Fuenmajor MC, Platts-Mills TAE. Quantitative assessments of IgG and IgE antibodies to inhalant allergens in patients with atopic dermatitis. J Allergy Clin Immunol 1983: 72: 27–33. 20 Conroy MC, Zhou T, Spengler H, DE Weck AL. IgG4 as blocking or anaphylactic antibody. In: JW Kerr, MA Ganderton, eds. Proceedings XI International Congress of Allergology and Clinical Immunology, London, 1982. London : Macmillan, 1983: 341–5. 21 de Groot H. Allergens from cats and dogs. PhD thesis. Amsterdam : University of Amsterdam, 1990. 22 Desvaux FX, Peltre G, David B. Characterization of grass pollen-specific IgE, IgA, IgM classes and IgG subclasses in allergic patients. Int Arch Allergy Appl Immunol 1989: 89: 281–7. 23 Devey ME, Lee SR, Richards D, Kemeny DM. Serial studies on the functional affinity and heterogeneity of antibodies of different IgG subclasses to phospholipase A, produced in response to bee-venom immunotherapy. J Allergy Clin Immunol 1989: 84: 326–30. 24 Devey ME, Wilson DV, Wheeler AW. The IgG subclasses of antibodies to grass pollen allergens produced in hay fever patients during hyposensitization. Clin Allergy 1976: 6: 227–36. 25 Djurup R. The subclass nature and clinical significance of the IgG antibody response in patients undergoing allergen-specific immunotherapy. Allergy 1985: 40: 469–86. 26 Fagan DL, Slaughter CA, Capra JD, Sullivan TJ. Monoclonal antibodies to immunoglobulin G4 induce histamine release from human basophils in vitro. J Allergy Clin Immunol 1982: 70: 399–404. 27 Gascan H, Gauchat J, Roncarolo M, Yssel H, Spits H, DE Vries JE. Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4 + T cell clones. J Exp Med 1991: 173: 747–50. 28 Gascan H, Gauchat J-F, Aversa G, Van Vlasselaer P, DE Vries JE. Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways. J Immunol 1991: 47: 8–13. 29 Gondo A, Saeki N, Tokuda Y. IgG4 antibodies in patients with atopic dermatitis. Br J Dermatol 1987: 117: 301–10. 30 Goodwin BFJ. Nonreaginic anaphylactic antibodies in man. In: GM Halpern, ed. Clinical reviews in allergy. Vol. 1. New York : Elsevier. 1983: 249–58. 31 Gwynn CM, Shakib F. IgG subclasses in skin disorders. Monogr Allergy 1986: 19: 198–201. 32 Hagan P, Blumenthal UJ, Dunn D, Simpson AJG, Wilkins HA. Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium. Nature 1991: 349: 243–5. 33 Homburger HA, Mauer K, Sachs Ml, O'Connel EJ, Jacob GL, Caron JC. Serum IgG4 concentrations and allergen-specific lgG4 antibodies compared in adults and children with asthma and nonallergic subjects. J Allergy Clin Immunol 1986: 77: 427–34. 34 Husby S, Larsen FS, Ahlstedt S, Svehag SE. Humoral immunity to dietary antigens in atopic dermatitis. II. Analysis of IgE and IcG subclass antibodies. Allergy 1986: 41: 386–91. 35 Hussain R, Ottesen EA. IgE responses in human filariasis. IV. Parallel antigen recognition of IgE and IgG4 subclass antibodies. J Immunol 1986: 136: 1859. 36 Hussain R, Poindexter RW, Ottesen EA. Control of allergic reactivity in human filariasis: predominant localization of blocking antibody to the IgG4 subclass. J Immunol 1992: 148: 2731–7. 37 Hvatum M, Scott H, Brandtzaeg P. Serum IgG subclass antibodies to a variety of food antigens in patients with coeliac disease. Gut 1992: 33: 632–8. 38 Ishizaka A, Sakiyama Y, Nakanishi M, et al. The inductive effect of interleukin-4 on lgG4 and IgE synthesis in human peripheral blood lymphoeytes. Clin Exp Immunol 1990: 79: 392–6. 39 Jimeno L, Lombardero M, Carreira J, Moscoso DEL Prado J. Presence of lgG4 on the membrane of human basophils. Histamine release is induced by monoclonal antibodies directed against Fab but not the Fc region of the IgG4 molecule. Clin Exp Allergy 1992: 22: 1007–14. 40 Kemeny DM, Price JF, Richardson V, Richards D, Lessof MH. The IgE and IgG subclass antibody response to foods in babies during the first year of life and their relationship to feeding regimen and the development of food allergy. J Allergy Clin Immunol 1991: 87: 920–9. 41 Kinet JP, Adamczewski M, Brini A, et al. Structure and function of FcαRI and of "new" receptors for immunoglobulin E. In: B Wüthrich, ed. Highlights in allergy and clinical immunology. Göttingen : Hogrefe & Huber, 1992: 28–9. 42 Koshte VL, Aalbers M, Calkhoven PG, Aalberse RC. The potent IgG4-indueing antigen in banana is a mannose-binding lectin, BanLec-I. Int Arch Allergy Appl Immunol 1992: 97: 17–24. 43 Kraut A, Peng Z, Becker AB, Warren CPW. Christmas candy maker's asthrna: lgG4-niediated pectin allergy. Chest 1992: 102: 1605–7. 44 Kurniawan A, Yazdanbakhsh M, Van Ree R, et al. Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis. J Immunol 1993: 150: 1–10. 45 Kwan-Lim G-E, Forsyth KP, Maizels RM. Filarial-specific IgG4 response correlates with active Wuchereria bancrofti infection. J Immunol 1990: 145: 4298–305. 46 Lee D, Edwards RG, Dewdney JM. Measurement of IgG subclasses in the sera of laboratory workers exposed to rats. Int Arch Allergy Appl Immunol 1988: 87: 222–4. 47 Lichtenstein LM, Kagey-Sobotka A, White JM, Hamilton RG. Anti-human IgG causes basophil histamine release by acting on IgG-IgE complexes bound to IgE receptors. J Immunol 1992: 148: 3929–36. 48 Lucas AH. IgG subclass-restricted immune responses to allergens. Springer Semin Immunopathol 1992: 12: 385–400. 49 Lundgren M, Persson U, Earsson P, et al. Interleukin 4 induces synthesis of IgE and IgG4 in human B cells. Eur J Immunol 1989: 19: 1311–15. 50 Mandler R, Finkelman FD, Eevine AD, Snapper CM. IL-4 induction of IgE class switching by lipopolysaccharide-activated murine B cells occurs predominantly through sequential switching. J Immunol 1993: 150: 407–18. 51 Merrett J, Barnetson RS, Burr ML, Merrett TG. Total and specific lgG4 antibody levels in atopic eczema. Clin Exp Immunol 1984: 56: 645–52. 52 Morgan JE, Daul CB, Lehrer SB. The relationships among shrimp-specific IgG subclass antibodies and immediate adverse reactions to shrimp challenge. J Allergy Clin Immunol 1990: 86: 387–92. 53 Mudde GC, Hansel TT, Van Reusen FC, Osterhoff BF, Bruijnzeel-Koomen CAFM. IgE: an immunoglobulin specialized in antigen capture. Immunol Today 1990: 11: 440–3. 54 Mudde GC, van Reusen FC, Boland GJ, de Gast GC, Bruunzebl PLB, Bruijnzeel-Koombn Cafm. Allergen presentation by epidermal Langerhans" cells from patients with atopic dermatitis is mediated by IgE. Immunology 1990: 69: 335–41. 55 Akagawa T, de Weck AL. Membrane receptors for the IgG4 subclass on human basophils. In: GM Halpern, ed. Clinical reviews in allergy. Vol. 1. New York : Elsevier, 1983: 197–206. 56 Naicagawa T, Mukoyama T, Baba M, Sakai Y, YA-Mashita N, Miyamoto T. Egg white-specific IgE and Ic:G4 antibodies in atopic children. Ann Allergy 1986: 57: 359–62. 57 Nelson HS, Branch LB. Incidence of IgG short-term sensitizing antibodies in an allergic population. J Allergy Clin Immunol 1977: 60: 266–70. 58 Nordvall SL, Renck B, Einarsson R. Specific IgE and IgG antibody responses in children to timothy pollen components during immunotherapy. Allergy 1989: 44: 380–4. 59 Nusslein HC, Spiegelberg HL. The role of lymphokines in IgE and IgG subclass formation. In: WJ Pichler, BM Stad-Ler, CA Dahinden, et al., eds. Progress in allergy and clinical immunology. Vol. I. Toronto : Hans Huber, 1989: 149–51. 60 Oehling A, Sanz ML, Garcia BE. Immunological parameters in the immunotherapy follow-up. Int Arch Allergy Immunol 1992: 99: 474–7. 61 Parish WE. Skin sensitizing non-IgE antibodies. Association between human IgG S-TS and IgG4. In: L Brent, J Holborow, eds. Progress in immunology. II. Part 4. North Holland, 1974: 19–28. 62 Pecquet C, Murrieta M, Michelen V, et al. Blocking activity of mite-specific IgG antibodies studied by skin-tests. Allergy 1989: 44: 427–31. 63 Peng Z, Naclerio RM, Norman PS, Adkinson NF Jr. Quantitative IgE- and IgG-subclass responses during and after long-term ragweed immunotherapy. J Allergy Clin Immunol 1992: 89: 519–29. 64 Perelmutter L. IgG4 and the immune system. In: GM Halpern, ed. Clinical reviews in allergy. Vol. 1. New York : Elsevier, 1983: 267–87. 65 Persson MAA, Brown SE, Steward MW, et al. IgG subclass-associated affinity differences of specific antibodies in humans. J Immunol 1988: 140: 3875–9. 66 Platts-Mills TAE. Local production of IgG, IgA and IgE antibodies in grass pollen hay fever. J Immunol 1979: 122: 2218–25. 67 Poulsen LK, Stahl Skov P, Mosbech H, Weeke B. Role of IgG4 in histamine release from human basophil leucocytes. 1. Sensitization of cells from normal donors. Int Arch Allergy Appl Immunol 1988: 86: 383–90. 68 Reinhold U, Pawelec G, Wehrmann W, Herold M, Wernet P, Kre Ysel HW. Immunoglobulin E and immunoglobulin G subclass distribution in vivo and relationship to in vitro generation of interferon-gamma and neopterin in patients with severe atopic dermatitis. Int Arch Allergy Appl Immunol 1988: 87: 120–6. 69 Rihet P, Dembure CE, Dessein AJ, Bourgois A. Strong serum inhibition of specific IgE correlated to competing IgG4, revealed by a new methodology in subjects from an 5. niansoni endemic area. Eur J Immunol 1992: 22: 2063–70. 70 Rihet P, Dbmeure CE, Ouattara M, et al. Immunological mechanisms of human resistance to schistosome infection: the protective effect of immunoglobulin E is balanced by a blocking action of immunoglobulin G4. In: P Godard, J Bousquet, FB Michel, eds. Advances in allergology and clinical immunology (EAACI XV, Paris 1992). Carnforth ( UK ) : Parthenon, 1992: 83–91. 71 Rogers BL, Morgenstern JP, Garman RD, Bond JF, Kuo M-C. Expression of recombinant Fel d I: expression, purification, IgE binding and reaction with cat allergic human T cells. Mol Immunol 1993 (in press). 72 Rowntree S, Mitchell EB, Platts-Mills TAE. Assessment of skin reactivity and specific antibody to egg and milk proteins in patients with atopic dermatitis: comparison with responses to the house dust mite antigen. Int Arch Allergy Appl Immunol 1986: 79: 132–9. 73 Rowntree S, Platts-Mills TAE, Cogswell JJ, Mitchell EB. A subclass IgG4-specific antigen-binding radioimmunoassay (RIA): comparison between IgG and IgG4 antibodies to food and inhaled antigens in adult atopic dermatitis after desensitization treatment and during development of antibody responses in children. J Allergy Clin Immunol 1987: 80: 622–30. 74 Shakib F. Basic and clinical aspects of IgG subclasses. Basel : Karger, 1987. 75 Shakib F, Brown HM, Redhead R, Phelps A. IgE and IgG4 antibodies to bovine milk fat globule membrane in atopic eczema patients: a study of their occurrence, relevance and antigenic specificity. Clin Allergy 1985: 265–71. 76 Shakib F, Brown HM, Stanworth DR. Relevance of milk- and egg-specific IgG4 in atopic eczema. Int Arch Allergy Appl Immunol 1984: 75: 107–12. 77 Shakib F, Mclaughlin P, Stanworth DR, Smith E, Fairbairn E. Elevated serum IgE and IgG4 in patients with atopic dermatitis. Br J Dermatol 1977: 97: 59. 78 Shakib F, Mills CS, Powell-Richards A. The recognition of a recombinant human Fcα fragment by the subclasses of IgG autoanti-IgE: disproportional subclass distribution of complexed autoantibody. Int Arch Allergy Appl Immunol 1992: 97: 243–8. 79 Snapper CM, Mond JJ. Towards a comprehensive view of immunoglobulin class switching. Immunol Today 1993: 14: 15–17. 80 Snow ME, Amzel LM. A molecular-mechanics study of the conformation of the interchain disulfide of human immunoglobulin G4 (lgG4). Mol Immunol 1988: 25: 1019–24. 81 Spiegelberg HL. FC receptors for IgE and interleukin-4 induced IgE and IgG4 secretion. J Invest Dermatol 1990: 94 (Suppl.): 49S–52S. 82 Spiegelberg HL. The role of interleukin-4 in IgE and IgG subclass formation. Springer Semin Immunopathol 1990: 12: 365–83. 83 Spiegelberg HL, Falkoff RJM, O'Connor RD, Beck L. Interleukin-2 inhibits the interleukin-4-induced human IgE and IgG4 secretion in vitro. Clin Exp Immunol 1991: 84: 400–5. 84 Spiegelberg HL, O'Connor RD, Falkoff RJM, Beck L. Interleukin-4 induced IgE and IgG4 secretion by B cells from atopic dermatitis patients. Int Arch Allergy Appl Immunol 1991: 94: 181–3. 85 Stanworth DR. IgG4 antibodies in atopics and their families. In: JW Kerr, MA Ganderton, eds. Proceedings XI International Congress of Allergology and Clinical Immunology, London, 1982. London : Macmillan, 1983: 337–40. 86 Stanworth DR, Smith K. Inhibition of reagin-mediated PCA reactions in baboons by the human IgG4 subclass. Clin Allergy 1973: 3: 37–41. 87 Stapel SO, van der Zee JS, Aalberse RC. Role of lgG4. EAACI proceedings. 1986: 13: 377–80. 88 Takizawa F, Adamczewski M, Kinet J-P. Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as FegammaRII and FegammaRIII. J Exp Med 1992: 176: 469–76. 89 Urbanek R, Collet M. Changes in skin and mucosa sensitivity correlated with specific IgE- and IgG-subclass antibodies in hyposensitized patients. In: WJ Pichler, BM Stadler, CA Dahinden, et al, eds. Progress in allergy and clinical immunology. Vol. I. Toronto : Hans Huber, 1989: 391–4. 90 Valent P, Betelheim P. Cell surface structures on human basophils and mast cells: biochemical and functional characterization. In: FJ Dixon, ed. Advances in immunology. San Diego , CA : 1992: 333–423. 91 van de Giessen M, Homan WL, van Kernebeek G, Aalberse RC, Dieges PH. Subclass typing of IgG antibodies formed by grass pollen-allergic patients during immunotherapy. Int Arch Allergy Appl Immunol 1976: 50: 625–40. 92 van der Zee JS, Aalberse RC. The role of IgG in allergy. In: MH Lessof, TH Lee, DM Kemeny, eds. Allergy: an international textbook. London : Wiley, 1987: 49–67. 93 van der Zee JS, Aalberse RC. Immunochemical characteristics of IgG4 antibodies. NER Allergy Proc 1988: 9: 31–3. 94 van der Zee JS, van Swieten P, Aalberse RC. Serologic aspects of lgG4 antibodies. II. IgG4 antibodies form small, nonprecipitating immune complexes due to functional monovalency. J Immunol 1986: 137: 3566–71. 95 van der Zee JS, van Swieten P, Aalberse RC. Inhibition of complement activation by IgG4 antibodies. Clin Exp Immunol 1986: 64: 415–22. 96 van Milligen FJ. The human antibody response to the cat allergen Felis domesticus. Enschede , The Netherlands : FEBO, 1993. 97 de Mllligen FJ., Craig S, Rogers BL, van Swieten P, Aalberse RC. Differences between specificities of IgE and IgG4 antibodies: studies using recombinant chain 1 and chain 2 of the major cat allergen Fel d I. J Allergy Clin Immunol 1993 (in press). 98 van Mllligen FJ, van't Hof W., Aalberse RC. IgE and lgG4 binding to synthetic peptides of the cat (Felis domesticus) major allergen Fel d. I Int Arch Allergy Immunol 1993 (in press). 99 van Mllligen FJ, van Swieten P., Aalberse RC. IgE and IgG4 to phylogenetic variants of the cat (Felis domesticus) major allergen Fel d I. Allergy 1993 (in press). 100 van Ree R, Stapel SO, Aalberse RC. Reverse-sandwich ELISA may underestimate antibody titers. J Allergy Clin Immunol 1989: 84: 562–3. 101 van Toorenenbergen AW, Aalberse RC. IgG4 and passive sensitization of basophil leukocytes. Int Arch Allergy Appl Immunol 1981: 65: 432–40. 102 van Toorenenbergen AW, Aalberse RC. IgG4 and release of histamine from human peripheral blood leukocytes. Int Arch Allergy Appl Immunol 1982: 67: 117–22. 103 van Toorenenbergen AW., Aalberse RC. Allergen-specific IgE and IgG4 antibody levels in sera and the capacity of these sera to sensitize basophil leucocytes in vitro. Clin Allergy 1982: 12: 451–8. 104 Vijay HM, Perelmutter L. Inhibition of reagin-mediated PCA-reactions in monkeys and histamine release from human leucocytes by human lgG4 subclass. Int Arch Allergy Appl Immunol 1977: 53: 78–87. 105 Wamae CN, Roberts JM, Eberhard ML, Lammie PJ. Kinetics of circulating human IgG4 after diethylcarbamazine and ivermectin treatment of bancroftian filariasis. J Infect Dis 1992: 165: 1158–60. 106 Wüthrich B, Benz A, Skvaril F. IgE and IgG4 levels in children with atopic dermatitis. Dermatologica 1983: 166: 229–35. Citing Literature Volume48, Issue8November 1993Pages 559-569 ReferencesRelatedInformation

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