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Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion

2009; Elsevier BV; Volume: 19; Issue: 7 Linguagem: Inglês

10.1016/j.bmcl.2009.02.002

1464-3405

Kazuhiro Kunimasa, Sachi Kuranuki, Nobuyasu Matsuura, Nozomi Iwasaki, Megumi Ikeda, Akira Ito, Yutaka Sashida, Yoshihiro Mimaki, Masamichi Yano, Mayumi Sato, Yasuhiro Igarashi, Tsutomu Oikawa,

Phytochemicals and Antioxidant Activities

Adiponectin, an adipocyte-derived protein with insulin-sensitizing, anti-diabetic and anti-atherogenic activities, is known to be induced during adipocyte differentiation. Nobiletin, a citrus polymethoxy flavonoid, was found to induce the differentiation of ST-13 preadipocytes into mature adipocytes and enhance the production of adiponectin protein at a concentration of 10 μM.