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Potential Biosoluble Carriers: Biocompatibility and Biodegradability of Oxidized Cellulose

1979; Marcel Dekker; Volume: 7; Issue: 4 Linguagem: Inglês

10.3109/10731197909118964

0090-5488

Maninder Singh, Alok R. Ray, Padma Vasudevan K. Verma, Sujoy K. Guha,

Electrospun Nanofibers in Biomedical Applications

The biocompatibility and biodegradability of periodate oxidized cellulose is assessed in vivo. Morophological and histopathological studies over a period of six months indicate that oxidized cellulose degrades slowly without producing excessive tissue reaction. Preliminary investigations on the kinetics of degradation of oxidized cellulose in vitro, immobilization of alpha-chymotrypsin on it and the rate of the enzyme release in a solution of pH 7.4 are also briefly reported.