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Involvement of Extracellular Signal-Regulated Kinase in Nobiletin-Induced Melanogenesis in Murine B16/F10 Melanoma Cells

2007; Oxford University Press; Volume: 71; Issue: 7 Linguagem: Inglês

10.1271/bbb.70088

1347-6947

Hoon-Seok Yoon, Sun-Ryung Lee, Hee‐Chul Ko, Soo‐Youn Choi, Ji‐Gweon Park, Jeong‐Kook Kim, Se‐Jae Kim,

Bioactive natural compounds

Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.