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Macrophage-colony stimulating factor (M-CSF) in the cerebrospinal fluid

1990; Elsevier BV; Volume: 29; Issue: 1-3 Linguagem: Inglês

10.1016/0165-5728(90)90152-d

1872-8421

Paolo Gallo, Silvana Pagni, Bruno Giometto, Maria Grazia Piccinno, Fernando A. Bozza, V. Argentiero, B. Tavolato,

Bacterial Infections and Vaccines

In a series of 145 cases with neurological diseases, macrophage-colony stimulating factor (M-CSF) was detected in cerebrospinal fluid of patients with brain tumors, bacterial meningitis, and less frequently, AIDS-dementia complex. Granulocyte-colony stimulating factor (G-CSF) was found only in patients with bacterial meningitis; granulocyte-macrophage (GM)-CSF was never detected. These findings suggest that M-CSF may play an important intrathecal immunoregulatory role in neoplastic and infectious diseases of the central nervous system.