The Conserved Sporulation Protein YneE Inhibits DNA Replication in Bacillus subtilis
2009; American Society for Microbiology; Volume: 191; Issue: 11 Linguagem: Inglês
10.1128/jb.00216-09
ISSN1098-5530
AutoresLilah Rahn-Lee, Boris Gorbatyuk, Ole Skovgaard, Richard Losick,
Tópico(s)DNA Repair Mechanisms
ResumoCells of Bacillus subtilis triggered to sporulate under conditions of rapid growth undergo a marked decrease in chromosome copy number, which was partially relieved by a mutation in the sporulation-induced gene yneE. Cells engineered to express yneE during growth were impaired in viability and produced anucleate cells. We conclude that YneE is an inhibitor of DNA replication.
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