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Testicular growth, sperm concentration, percent motility, and pregnancy outcome after varicocelectomy based on testicular histology

2005; Elsevier BV; Volume: 83; Issue: 2 Linguagem: Inglês

10.1016/j.fertnstert.2004.06.067

1556-5653

Fábio Firmbach Pasqualotto, Antonio Marmo Lucón, Plínio Moreira de Góes, Jorge Hallak, Bernardo Passos Sobreiro, Eleonora Bedin Pasqualotto, Sami Arap,

Sexual Differentiation and Disorders

Objective To evaluate the outcome following surgery in two different patterns of testicular histology in patients with varicocele. Design Prospective study. Setting Academic medical center. Patient(s) Sixty patients underwent varicocelectomy and had a testicular histology diagnosis of germ-cell aplasia (group I, n=28) or maturation arrest (group II, n=32). Intervention(s) Varicocelectomy. Main outcome measure(s) Preoperative hormone levels, testicular size, and sperm parameters. After varicocelectomy, variations in testicular size, semen parameters, and pregnancy rates were evaluated. Result(s) The mean volume of the right and left testicle was smaller in group I patients than in group II. In addition, the mean sperm concentration before treatment was lower in group I than in group II. The mean volume of the left and right testicle increased in group I after the intervention. The mean postoperative sperm concentration and motility in group II showed no increase, whereas the mean sperm concentration in group I did increase. The pregnancy rate was higher in group II (14/26, 53.8%) than in group I (4/16, 25%) ( P =.02). Conclusion(s) Patients with germ-cell aplasia present a postoperative increase in testicular size but the pregnancy rate is higher in patients with maturation arrest following surgery.