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Synthesis and bio-evaluation of aryl hydrazono esters for oviposition responses in Aedes albopictus

2010; Elsevier BV; Volume: 21; Issue: 2 Linguagem: Inglês

10.1016/j.bmcl.2010.11.101

1464-3405

Prabal Bandyopadhyay, Lopamudra Guha, T. Seenivasagan, Manisha Sathe, Pratibha Sharma, B. D. Parashar, M. P. Kaushik,

Malaria Research and Control

A novel series of aryl hydrazono esters (AHE) (1-13) were synthesized (yield 76-98%) to study the oviposition responses in Aedes albopictus (Skuse) mosquitoes for the first time. At a concentration of 10μgml(-1) in dual choice experiment, among the screened compounds, AHE-12 showed remarkable oviposition attractant activity with an oviposition activity index (OAI) of +0.299 (greater than 95% confidence limit) comparable to p-cresol (OAI +0.320) which is well-reported oviposition attractant for Aedes aegypti. Conversely, AHE-10 exhibited highest oviposition deterrent activity with OAI -0.247. The possible utilization of these compounds will be in integrated vector management strategies.