Vertebral compression fracture after stereotactic body radiotherapy for spinal metastases
2013; Elsevier BV; Volume: 14; Issue: 8 Linguagem: Inglês
10.1016/s1470-2045(13)70101-3
ISSN1474-5488
AutoresArjun Sahgal, Cari Whyne, Lijun Ma, David A. Larson, Michael G. Fehlings,
Tópico(s)Spine and Intervertebral Disc Pathology
ResumoThe use of stereotactic body radiotherapy for metastatic spinal tumours is increasing. Serious adverse events for this treatment include vertebral compression fracture (VCF) and radiation myelopathy. Although VCF is a fairly low-risk adverse event (approximately 5% risk) after conventional radiotherapy, crude risk estimates for VCF after spinal SBRT range from 11% to 39%. In this Review, we summarise the evidence and predictive factors for VCF induced by spinal SBRT, review the pathophysiology of VCF in the metastatic spine, and discuss strategies used to prevent and manage this potentially disabling complication.
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