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On-Demand Generation of an Efficient Catalyst for Pyridine Formation from Unactivated Nitriles and α,ω-Diynes Using CoCl 2 -6H 2 O, dppe, and Zn

2007; American Chemical Society; Volume: 9; Issue: 5 Linguagem: Inglês

10.1021/ol070037p

1523-7060

Kouki Kase, Avijit Goswami, Kazuhiko Ohtaki, Emi Tanabe, Naoko Saino, Sentaro Okamoto,

Click Chemistry and Applications

A highly practical, general method for catalytic formation of substituted pyridines from a variety of unactivated nitriles and α,ω-diynes is given. The reactions which were catalyzed by 5 mol % of dppe/CoCl2−6H2O in the presence of Zn powder (10 mol %) could proceed at rt to ∼50 °C with high functional compatibility and regioselectivity.