Specificity of delayed reactions to hapten-polypeptide conjugates
1965; Elsevier BV; Volume: 2; Issue: 4 Linguagem: Inglês
10.1016/0019-2791(65)90032-7
ISSN1878-237X
Autores Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoGuinea pigs sensitized with p-azobenzenearsonate conjugates of polytyrosine, poly Lys51Tyr49, poly Glu52Tyr48 and poly Ala34Glu36Tyr30, showed delayed cross-reactions with p-azobenzenearsonate conjugate of bovine serum albumin. When conjugates of poly-peptides containing other haptens such as p-azobenzoate, p-azobenzenesulfonate and p-nitrophenylazo were used as sensitizing antigens, no delayed cross-reactions were observed with the corresponding hapten-bovine serum albumin conjugates, in conformity with the “carrier-specificity” known to exist in most delayed hypersensitivity reactions.
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