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Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children

2010; Elsevier BV; Volume: 28; Issue: 44 Linguagem: Inglês

10.1016/j.vaccine.2010.08.063

1873-2518

Michael E. Pichichero, Ravinder Kaur, Janet R. Casey, Albert Sabirov, M. Nadeem Khan, Anthony Almudevar,

Respiratory viral infections research

Development of natural antibodies to 3 nontypeable Haemophilus influenzae (NTHi) outer membrane proteins (D, P6 and OMP26) was prospectively studied in 130 children 6–30 months of age during NP colonization and acute otitis media (AOM). IgG antibody to protein D, P6 and OMP26 increased with age (p < 0.001). Serum IgG responses to NP colonization were different for the 3 proteins: protein D responses occurred at a later age than P6, and OMP26 responses were minimal. For all 3 proteins serum antibody levels in the convalescent phase of AOM infection were not as high as after NP colonization. Antibodies to protein D and P6 but not OMP26 were bactericidal.