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TWO CONSECUTIVE SETS OF TRANSRECTAL ULTRASOUND GUIDED SEXTANT BIOPSIES OF THE PROSTATE FOR THE DETECTION OF PROSTATE CANCER

1998; Lippincott Williams & Wilkins; Volume: 159; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(01)63951-x

1527-3792

Michael A. Levine, Michael Ittman, Jonathan Melamed, Herbert Lepor,

Prostate Cancer Treatment and Research

No AccessJournal of UrologyClinical Urology: Original Articles1 Feb 1998TWO CONSECUTIVE SETS OF TRANSRECTAL ULTRASOUND GUIDED SEXTANT BIOPSIES OF THE PROSTATE FOR THE DETECTION OF PROSTATE CANCER Michael A. Levine, Michael Ittman, Jonathan Melamed, and Herbert Lepor Michael A. LevineMichael A. Levine , Michael IttmanMichael Ittman , Jonathan MelamedJonathan Melamed , and Herbert LeporHerbert Lepor View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63951-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated the role of performing 2 consecutive sets of transrectal ultrasound guided sextant biopsies of the prostate in a single office visit as the protocol for detecting prostate cancer in men presenting for the first time with an abnormal digital rectal examination and/or elevated serum prostate specific antigen (PSA). Materials and Methods: A total of 137 consecutive men presenting for the first time with a clinically localized prostate nodule on digital rectal examination and/or elevated serum PSA based upon age specific reference ranges underwent 2 consecutive sets of sextant prostate biopsies under transrectal ultrasound guidance in a single office visit. The 2 sets of biopsies were processed and analyzed separately by pathologists. Results: Adenocarcinoma of the prostate was diagnosed in 43 of the patients (31%) undergoing biopsy. Adenocarcinoma of the prostate was diagnosed in only the second set of biopsies in 13 cases (10%). High grade prostatic intraepithelial neoplasia without adenocarcinoma of the prostate was observed in 18 of the first set of biopsies (15%). High grade intraepithelial neoplasia without adenocarcinoma of the prostate was the only pathological diagnosis in the second set of biopsies in 3 cases. The second set of biopsies provided important new clinical information related to prostate cancer in 20 cases (28%) and increased the number of cancers detected by 30%. In addition, 14 patients with high grade intraepithelial neoplasia who would have required a second set of biopsies were found not to have adenocarcinoma of the prostate. Prostate cancer was detected in 43, 27 and 24% of men with prostate volumes less than 30, 30 to 50 and greater than 50 cc, respectively. The percentage of prostate cancers detected only in the second set of biopsies was not significantly related to prostate size. Conclusions: Two consecutive sets of transrectal ultrasound guided sextant biopsies of the prostate performed in a single office visit represent a cost-effective biopsy strategy for men presenting with an abnormal digital rectal examination and/or elevated serum PSA. 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(2018) EDITORIAL COMMENTJournal of Urology, VOL. 160, NO. 2, (418-419), Online publication date: 1-Aug-1998. Volume 159Issue 2February 1998Page: 471-476 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.Metrics Author Information Michael A. Levine More articles by this author Michael Ittman More articles by this author Jonathan Melamed More articles by this author Herbert Lepor More articles by this author Expand All Advertisement PDF downloadLoading ...