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BIBTEX RIS

Human papillomavirus among women with atypical squamous cells of undetermined significance in southern Brazil

2014; Elsevier BV; Volume: 128; Issue: 1 Linguagem: Inglês

10.1016/j.ijgo.2014.07.027

1879-3479

Suelen Paesi, Leonardo Alves Corrêa, Márcia Caldart Tregnago, Jovana Mandelli, Mariana Roesch‐Ely,

Hepatitis B Virus Studies

Abstract Objective To determine the prevalence of atypical squamous cells of undetermined significance (ASCUS) and human papillomavirus (HPV) genotypes in a population in southern Brazil. Methods In a retrospective cross‐sectional study, the prevalence of ASCUS was determined among women aged 20–60 years who were referred to a private medical center in Caxias do Sul by a gynecologist for assessment of a cervical condition between January 1, 2010, and September 30, 2011. Histologic and cytologic samples were tested for HPV, and polymerase chain reaction (PCR) was used to genotype any HPV DNA identified. Results Among the 250 included women, 25 (10.0%) had ASCUS. HPV DNA was found in 15 (60.0%) women with ASCUS and 115 (51.1%) of the 225 without ASCUS. Viral typing showed that 7 (46.7%) HPV‐positive women with ASCUS had multiple infections with up to five different genotypes. Both low‐ and high‐risk HPV genotypes were found in ASCUS samples; the most prevalent genotypes were HPV6/HPV11 (affecting 10 [66.7%] women), HPV51 (6 [40.0%]), and HPV16 (6 [40.0%]). Conclusion ASCUS is not an indication of HPV infection. HPV screening and genotyping would benefit women with ASCUS, because treatment can be planned according to risk of carcinogenesis.