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Does "Blastocyst Estrogen" Initiate Implantation?

1977; American Association for the Advancement of Science; Volume: 195; Issue: 4279 Linguagem: Inglês

10.1126/science.841306

1095-9203

Z. Dickmann, Jayasree Sen Gupta, Sudhansu K. Dey,

Synthesis and Biological Evaluation

Fertilized eggs were incubated for 2 hours in a medium containing estradiol-17beta and then transferred into the uteri of day 5 pseudopregnant rats. These eggs, but not estrogen-free control eggs, induced a local increase in capillary permeability. We suggest that the blastocyst factor which induces the local increase in capillary permeability during early pregnancy is estrogen synthesized by the blastocyst.