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Cardiovascular and respiratory effects of Gaboon viper venom

1975; Elsevier BV; Volume: 6; Issue: 1 Linguagem: Inglês

10.1016/0306-3623(75)90009-9

1879-0011

B.C. Whaler,

Neurobiology and Insect Physiology Research

1. Doses of venom (rabbit 0·7–2·7 mg/kg; monkey 0·20–0·33 mg/kg) given intravenously and killing in 20–200 min produce a marked and maintained fall in blood pressure. 2. There is a progressive reduction in O2 consumption accompanied in rabbits with hyperventilation and terminal pulmonary oedema. 3. The heart is directly affected. 4. Blood becomes incoagulable and there is also extensive internal haemorrhage, particularly in visceral tissues.