Alkylation of Synthetic Polynucleotides
1964; American Association for the Advancement of Science; Volume: 145; Issue: 3630 Linguagem: Inglês
10.1126/science.145.3630.397
ISSN1095-9203
AutoresDavid B. Ludlum, Robert C. Warner, Albert J. Wahba,
Tópico(s)Advanced biosensing and bioanalysis techniques
ResumoThe synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine synthesis.
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