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Prostaglandins and the anti-inflammatory activities of aspirin and sodium salicylate

1975; Oxford University Press; Volume: 27; Issue: 7 Linguagem: Inglês

10.1111/j.2042-7158.1975.tb09487.x

2042-7158

Michael Smith, A. W. Ford‐Hutchinson, Peter Elliott,

Phytochemistry and Bioactive Compounds

Acetylsalicylic acid (aspirin) and sodium salicylate are equally effective in reducing the swelling in the carrageenan-induced paw test and the accumulation of leucocytes into the inflammatory exudate produced by the subcutaneous implantation of polyvinyl sponges in the rat. Aspirin but not sodium salicylate caused a significant reduction in the potentiation of paw oedema found after the concurrent administration of carrageenan and arachidonic acid. Some implications of these findings are discussed.