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New Insights Into Alzheimer's Disease Amyloid Inhibition: Nanosized Metallo‐Supramolecular Complexes Suppress Aβ‐Induced Biosynthesis of Heme and Iron Uptake in PC12 Cells

2013; Wiley; Volume: 3; Issue: 6 Linguagem: Inglês

10.1002/adhm.201300470

ISSN

2192-2659

Autores

Meng Li, Chuanqi Zhao, Taicheng Duan, Jinsong Ren, Xiaogang Qu,

Tópico(s)

Neuroinflammation and Neurodegeneration Mechanisms

Resumo

Advanced Healthcare MaterialsVolume 3, Issue 6 p. 832-836 Communication New Insights Into Alzheimer's Disease Amyloid Inhibition: Nanosized Metallo-Supramolecular Complexes Suppress Aβ-Induced Biosynthesis of Heme and Iron Uptake in PC12 Cells Meng Li, Meng Li Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022 ChinaSearch for more papers by this authorChuanqi Zhao, Chuanqi Zhao Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022 ChinaSearch for more papers by this authorTaicheng Duan, Taicheng Duan Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022 China National Analytical Research Center of Electrochemistry & Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin, 130022 ChinaSearch for more papers by this authorJinsong Ren, Jinsong Ren Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022 ChinaSearch for more papers by this authorXiaogang Qu, Corresponding Author Xiaogang Qu Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022 ChinaE-mail: [email protected]Search for more papers by this author Meng Li, Meng Li Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022 ChinaSearch for more papers by this authorChuanqi Zhao, Chuanqi Zhao Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022 ChinaSearch for more papers by this authorTaicheng Duan, Taicheng Duan Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022 China National Analytical Research Center of Electrochemistry & Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin, 130022 ChinaSearch for more papers by this authorJinsong Ren, Jinsong Ren Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022 ChinaSearch for more papers by this authorXiaogang Qu, Corresponding Author Xiaogang Qu Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022 ChinaE-mail: [email protected]Search for more papers by this author First published: 29 October 2013 https://doi.org/10.1002/adhm.201300470Citations: 9Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Nanosized metallo-supramolecular compounds, [Ni2L3]4+ and [Fe2L3]4+, can not only strongly inhibit Aβ aggregation but also reduce the peroxidase activity of Aβ–heme. Further studies demonstrate that through blocking the heme-binding site, these two compounds can suppress Aβ-induced biosynthesis of heme and iron uptake in PC12 cells. This work provides new insights into molecular mechanisms of Aβ inhibitors on Aβ-mediated neurotoxicity. References 1A. Rauk, Chem. Soc. Rev. 2009, 38, 2698. 2a) R. Jakob-Roetne, H. Jacobsen, Angew. Chem. Int. Ed. 2009, 48, 3030; b) L. E. Scott, C. Orvig, Chem. Rev. 2009, 109, 4885; c) E. Gaggelli, H. Kozlowski, D. Valensin, G. Valensin, Chem. Rev. 2006, 106, 1995; d) I. W. Hamley, Chem. Rev. 2012, 112, 5147. 3a) H. Atamna, W. H. Frey II, Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 11153; b) H. Atamna, K. Boyle, Proc. Natl. Acad. Sci. U. S. A. 2006, 103, 3381; c) C. Yuan, L. Yi, Z. Yang, Q. Deng, Y. Huang, H. Li, Z. 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Any queries (other than missing content) should be directed to the corresponding author for the article. Volume3, Issue6June, 2014Pages 832-836 ReferencesRelatedInformation

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