Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis
2001; Lippincott Williams & Wilkins; Volume: 56; Issue: 2 Linguagem: Inglês
10.1212/wnl.56.2.270
ISSN1526-632X
AutoresCarlo Ferrarese, Gessica Sala, Roberto Riva, Barbara Begni, C Zoia, Lucio Tremolizzo, G. Galimberti, Andrea Millul, Antonio Bastone, Tiziana Mennini, C Balzarini, L. Frattola, Ettore Beghi,
Tópico(s)Neurogenetic and Muscular Disorders Research
ResumoDecreased glutamate uptake and a loss of the astrocytic glutamate transporter EAAT2 (GLT-1) have been shown in spinal cord and motor cortex of patients with ALS. Because platelets express the three major glutamate transporter subtypes, including GLT-1, and possess a high-affinity glutamate uptake, the authors investigated glutamate uptake in platelets from patients with ALS and controls. A 43% reduction of high-affinity glutamate uptake rate (p < 0.0001) was observed in patients with ALS compared with normal controls and chronic neurologic disorder patients, suggesting a systemic impairment of glutamate uptake in ALS.
Referência(s)