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VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions

2014; National Academy of Sciences; Volume: 111; Issue: 48 Linguagem: Inglês

10.1073/pnas.1407227111

1091-6490

Victor H. Guaiquil, Zan Pan, Natalia Karagianni, Shima Fukuoka, Gemstonn Alegre, Mark I. Rosenblatt,

Nerve Injury and Rehabilitation

Significance Peripheral nerve injury is a major neurological disorder that can cause multiple motor and sensory disturbances. In this study we found that VEGF-B can be used as a previously unidentified therapeutic for treating peripheral nerve injury. We demonstrated that VEGF-B stimulated nerve regeneration and enhanced the recovery of both tissue sensation and the ability of nerves to enhance healing of innervated tissue. The physiologic relevance of VEGF-B is demonstrated by our findings showing that mice lacking VEGF-B have impaired nerve regeneration and that nerve injury resulted in increased endogenous expression of VEGF-B. We discover that VEGF-B induces strong elongation and branching of neurons and requires specific transmembrane receptors as well as activation of a complex intracellular signaling.