Portal de Periódicos da CAPES

Effects of MPTP on locomotor activity in mice

1990; Elsevier BV; Volume: 12; Issue: 4 Linguagem: Inglês

10.1016/0892-0362(90)90061-g

1872-9738

Víctor A. Colotla, Eduardo Flores‐Villalba, Alejandro Oscos, Alfredo Meneses, Ricardo Tapia,

Parkinson's Disease Mechanisms and Treatments

Thirty-two mice were randomly assigned to one of 4 groups of 8 animals each: the first received IP saline injections and the other 3 groups received 10, 20 or 30 mg/kg MPTP. Each dose or saline was administered 3 times in 3 consecutive days and locomotor activity was measured during the next 3 days. In addition, the animals were observed in 2 trials in a rotating rod (Rotarod) and a grip test. The 2 highest doses of the drug produced significant increases in locomotor activity. In the other two behavioral tests, the highest dose of MPTP significantly reduced the capability of the animals to remain on the Rotarod on the grid.