Efficacy and Toxicity of Doxorubicin/Cyclophosphamide Maintenance Therapy in Dogs with Multicentric Lymphosarcoma
1991; Wiley; Volume: 5; Issue: 5 Linguagem: Inglês
10.1111/j.1939-1676.1991.tb03131.x
ISSN1939-1676
AutoresG. Sylvester Price, Rodney L. Page, Bernard M. Fischer, Jay F. Levine, Thomas M. Gerig,
Tópico(s)Glycosylation and Glycoproteins Research
ResumoDoxorubicin/cyclophosphamide were evaluated as maintenance drugs for dogs with multicentric lymphosarcoma (n = 28). Median remission time of all dogs was 173 days. Remission duration was shorter, however, in dogs with stage IV/V disease, in dogs with pretreatment hypoalbuminemia, and in dogs that had received glucocorticoids before initiation of chemotherapy ( P < 0.04). Nineteen dogs were evaluable for toxicity. Dose‐limiting gastrointestinal toxicosis was observed in three dogs, neutropenia was observed in three dogs, and cardiomyopathy was observed in three dogs. The doxorubicin/cyclophosphamide protocol described in this report is safe and effective in treating canine multicentric lymphosarcoma. Clinical stage, pretreatment steroid therapy, and hypoalbuminemia are prognostic factors for response to this protocol
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