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BIBTEX RIS

Functional serotonin 5–HTTLPR polymorphism is a risk factor for migraine with aura

2005; Springer Nature; Volume: 6; Issue: 4 Linguagem: Inglês

10.1007/s10194-005-0179-9

ISSN

1129-2377

Autores

Barbara Borroni, Cristina Brambilla, Paolo Liberini, Renata Rao, Silvana Archetti, Stefano Gipponi, Giorgio Dalla Volta, Alessandro Padovani,

Tópico(s)

Cardiovascular Syncope and Autonomic Disorders

Resumo

In the present work, we report that the functional serotonin transporter gene promoter (5-HTTLPR) polymorphism is involved in migraine pathogenesis. The distribution of 5-HTTLPR genotypes was significantly different in MA patients (S/S vs. S/L vs. L/L=32.7 vs. 42.3 vs. 25.0%), MO patients (18.5 vs. 39.1 vs. 42.4%) and CON (18.0 vs. 51.3 vs. 30.7%; chi-square test, p<0.05). In 5-HTTLPR S/S carriers, the odds ratio for MA risk was 2.60 (95% confidence interval [95%CI]=1.75-3.85) compared to CON, and it was 2.14 (95%CI=1.42-3.21) compared to MO. These data provide a further insight on the complex genotype-phenotype relationship involved in MA pathogenesis, and might eventually result in new and individualised prognostic and therapeutic measures.

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