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The hairy ears ( Eh ) mutation is closely associated with a chromosomal rearrangement in mouse chromosome 15

1990; Cambridge University Press; Volume: 56; Issue: 2-3 Linguagem: Inglês

10.1017/s0016672300035266

1469-5073

Muriel T. Davisson, Thomas H. Roderick, Ellen C. Akeson, Norman L. Hawes, Hope O. Sweet,

Genomics and Chromatin Dynamics

Summary The mouse mutation hairy ears ( Eh ) originated in a neutron irradiation experiment at Oak Ridge National Laboratory. Subsequent linkage studies with Eh and other loci on Chr 15 suggested that it is associated with a chromosomal rearrangement that inhibits recombination since it shows tight linkage with several loci occupying the region extending from congenital goiter ( cog ) distal to caracul ( ca ). We report here (1) linkage experiments confirming this effect on recombination and (2) meiotic and mitotic cytological studies that confirm the presence of a chromosomal rearrangement. The data are consistent with the hypothesis of a paracentric inversion in the distal half of Chr 15. The effect of the inversion extends over a minimum of 30 cM, taking into account the genetic data and the cytologically determined chromosomal involvement extending to the region of the telomere.