Specific Chromosome Defect Associated with Human Small-Cell Lung Cancer: Deletion 3p(14-23)
1982; American Association for the Advancement of Science; Volume: 215; Issue: 4529 Linguagem: Inglês
10.1126/science.6274023
ISSN1095-9203
AutoresJ. Whang‐Peng, C. S. Kao-Shan, E. C. Lee, Paul A. Bunn, D. N. Carney, Adi F. Gazdar, John D. Minna,
Tópico(s)Cholangiocarcinoma and Gallbladder Cancer Studies
ResumoA specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion.
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