Portal de Periódicos da CAPES

On the Function and Structure of Synthetically Modified Porins

2009; Wiley; Volume: 48; Issue: 26 Linguagem: Inglês

10.1002/anie.200900457

1521-3773

Simon Reitz, Menekse Çebi, Philipp Reiß, Gregor Studnik, Uwe Linne, Ulrich Koert, Lars‐Oliver Essen,

Microfluidic and Capillary Electrophoresis Applications

Abstract The attachment of modulators to a trimeric porin ion channel was investigated (see picture of the trimer with a crown ether modulator (orange)). The interplay of modulator and protein is essential for the conformational heterogeneity of the hybrid channel. Single‐site attachment in large pores is not sufficient to change the electrophysiological characteristics of the pores—such change requires additional noncovalent interactions or second‐site attachments. magnified image