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Trichinosis with Neurologic and Cardiac Involvement

1962; American College of Physicians; Volume: 57; Issue: 2_Part_1 Linguagem: Inglês

10.7326/0003-4819-57-2-230

1539-3704

DEAN F. GRAY,

Parasite Biology and Host Interactions

Article1 August 1962Trichinosis with Neurologic and Cardiac InvolvementReview of the Literature and Report of Three CasesDEAN F. GRAY, M.D., BERNARD S. MORSE, M.D., WESLEY F. PHILLIPS, A.B.DEAN F. GRAY, M.D.Search for more papers by this author, BERNARD S. MORSE, M.D.Search for more papers by this author, WESLEY F. PHILLIPS, A.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-2-230 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptData on its incidence establish trichinosis as the most prevalent helminthic infestation of man. Autopsy information (1) and corroborative skin testing (2) indicate that 30,000,000 Americans, or one out of every 6, harborTrichinella spiralis. Obviously the overwhelming majority are asymptomatically parasitized. Although it is difficult to predict the number of symptomatic cases because of varying degrees of host resistance and sites of larval dissemination, it is estimated that 16,000 Americans yearly will consume sufficient viable larvae to cause detectable illness. The mortality rate for trichinosis is generally regarded as 5 to 6 per cent (3), from which 800 deaths...References1. GOULD SE: Trichinosis, Charles C Thomas, Springfield, Illinois, 1945. CrossrefGoogle Scholar2. SAWITZ W: Are post-mortem statistics on trichinosis valid for the living population? Amer. J. Public Health 27: 1023, 1937. CrossrefGoogle Scholar3. Editorial: Trichinosis. J. A. M. A. 152: 241, 1953. CrossrefMedlineGoogle Scholar4. MERRITTROSENBAUM HHM: Involvement of the nervous system in trichiniasis. J. A. M. A. 106: 1646, 1936. CrossrefGoogle Scholar5. HURD RW: Focal cerebral injury due to Trichinella spiralis. J. Nerv. Ment. Dis. 17: 526, 1953. CrossrefGoogle Scholar6. DALESSIOWOLFF DJHG: Trichinella spiralis infection of the central nervous system. Arch. Neurol. 4: 407, 1961. CrossrefMedlineGoogle Scholar7. KAGAN IG: Personal communication. Google Scholar8. KAGAN IG: Trichinosis, a review of biologic, serologic, and immunologic aspects. J. Infect. Dis. 107: 65, 1960. CrossrefGoogle Scholar9. INNELLAREDNER FWJ: Latex-agglutination serologic test for trichinosis. J. A. M. A. 171: 885, 1959. CrossrefMedlineGoogle Scholar10. SADUSK JF: Cortisone in treatment of trichinosis. Calif. Med. 81: 348, 1954. MedlineGoogle Scholar11. MCNAUGHT JB: The diagnosis of trichinosis. Amer. J. Trop. Med. 19: 181, 1939. CrossrefGoogle Scholar12. LEITNERGRYNKEWICH MJSE: Encephalopathy associated with trichinosis. Amer. J. Med. Sci. 236: 546, 1958. MedlineGoogle Scholar13. REIMANNPRICEHERBUT HAAHPA: Trichinosis and periarteritis nodosa. J. A. M. A. 122: 274, 1943. CrossrefGoogle Scholar14. BRUNOGOODGOLD MSM: Meningoencephalitis due to Trichinella spiralis. New York J. Med. 50: 707, 1950. Google Scholar15. WRIGHT WH: A consideration of the clinical and public health aspects of trichinosis. J. Lancet 62: 389, 1942. Google Scholar16. HARRELLAIKAWA GTJK: Alterations in the permeability of membranes during infection. J. A. M. A. 147: 232, 1951. CrossrefMedlineGoogle Scholar17. SALZER BJ: A study of an epidemic of fourteen cases of trichinosis with cures by serum therapy. J. A. M. A. 67: 579, 1916. CrossrefGoogle Scholar18. EVERS LB: Manifestations of trichiniasis in the central nervous system. Arch. Intern. Med. 63: 949, 1939. CrossrefGoogle Scholar19. SHELDON JH: An outbreak of trichiniasis in Wolverhampton and district. Lancet 1: 203, 1941. CrossrefGoogle Scholar20. FREEDMANCLAMEN SOM: A case of trichinosis simulating meningitis. Canad. Med. Ass. J. 71: 160, 1954. MedlineGoogle Scholar21. SEMPLEDAVIESKERSHAWST. HILL ABJBWECA: Outbreak of trichinosis in Liverpool in 1953. Brit. Med. J. 1: 1002, 1954. CrossrefMedlineGoogle Scholar22. MOSTABELES HMM: Trichiniasis involving the nervous system. Arch. Neurol. Psychiat. 37: 589, 1937. CrossrefGoogle Scholar23. SALANSCHWARTZ JB: Trichinosis with involvement of the central nervous system. J. A. M. A. 90: 611, 1928. CrossrefGoogle Scholar24. HORLICKBICKNESS SSRE: Trichiniasis with widespread infestation of many tissues. New Engl. J. Med. 201: 816, 1929. CrossrefGoogle Scholar25. SCOTTJOHNSONHOLZMAN RARED: Trichinosis with neurologic and mental manifestations. New Engl. J. Med. 247: 512, 1952. CrossrefMedlineGoogle Scholar26. HOUSTONROSS JCL: Trichiniasis with cerebral symptoms. Lancet 2: 397, 1941. CrossrefGoogle Scholar27. PUNDMOSTELLER ERR: Trichinosis: demonstration of the parasites in the brain. J. A. M. A. 102: 1220, 1934. CrossrefGoogle Scholar28. WALKER AT: Trichiniasis. J. A. M. A. 98: 2051, 1932. CrossrefGoogle Scholar29. STERLING W: Les troubles nerveux de la trichinose. Rev. Neurol. (Par.) 1: 435, 1925. Google Scholar30. DANDY WE: Infections of brain, meninges, and skull, in Lewis' Practice of Surgery, W. F. Prior Company, Inc., Hagerstown, Maryland, 1943. Google Scholar31. BLOCHHASSIN LGB: Trichinosis complicated by encephalitis. Med. Rec. 91: 537, 1917. Google Scholar32. ROEHM DC: Trichinosis: report of case manifesting myocarditis, encephalitis and radial neuritis; response to ACTH; review of literature regarding the erythrocyte sedimentation rate. Ann. Intern. Med. 40: 1026, 1954. LinkGoogle Scholar33. MELTZERBOCKMAN LEAA: Trichinosis involving the central nervous system. J. A. M. A. 164: 1566, 1957. CrossrefMedlineGoogle Scholar34. MACANDREWDAVIS ME: Trichiniasis presenting with foot-drop and facial palsy. Lancet 1: 141, 1948. CrossrefMedlineGoogle Scholar35. SHIELDSSMITHCOOKWITTELINDSEY LHDARWEJGD: A local outbreak of trichinosis. Ann. Intern. Med. 54: 734, 1961. LinkGoogle Scholar36. MAVOR H: Focal central-nervous-system involvement associated with trichinosis. New Engl. J. Med. 258: 648, 1958. CrossrefMedlineGoogle Scholar37. CAMPBELL WE: Psychoses with trichinosis. Rhode Island Med. J. 30: 870, 1947. MedlineGoogle Scholar38. SNAPENARDIBARSE WJMF: Persistent mental aberration associated with trichinosis. J. Med. Soc. New Jersey 53: 309, 1956. MedlineGoogle Scholar39. WHITTERIDGE SM: A case of Trichinella spiralis infection with mental symptoms. J. Roy. Nav. Med. Serv. 28: 290, 1942. CrossrefGoogle Scholar40. STERNDANCEY KTE: Acute psychosis associated with trichiniasis. Canad. Med. Ass. J. 48: 235, 1943. MedlineGoogle Scholar41. FROTHINGHAM C: A contribution to the knowledge of the lesions caused by Trichina spiralis in man. J. Med. Res. 15: 483, 1906. MedlineGoogle Scholar42. HELFANDHOUCKWEISMAN MKHFM: Trichinosis as a cause of encephalitis. Dis. Nerv. Syst. 13: 242, 1952. MedlineGoogle Scholar43. GORDONCARESKAUFMAN MDRB: Encephalitis and myocarditis in a fatal case of trichinosis. J. Pediat. 6: 667, 1935. CrossrefGoogle Scholar44. MARCUSMILLER SRV: An atypical case of trichinosis with report of electromyographic findings. Ann. Intern. Med. 43: 615, 1955. LinkGoogle Scholar45. DOWBEN RM: Diagnosis and treatment of muscle disease. Arch. Intern. Med. 107: 430, 1961. CrossrefMedlineGoogle Scholar46. SKINNER JC: Neurologic complications of trichinosis. New Engl. J. Med. 238: 317, 1948. CrossrefMedlineGoogle Scholar47. AIKAWAHARRELLMILLER JKGTTB: The immunophysiology of trichinosis; alterations in the blood volume and the thiocyanate space in relation to the development of humoral antibodies in the rabbit. J. Clin. Invest. 30: 575, 1951. CrossrefMedlineGoogle Scholar48. JACKSON GJ: Fluorescent antibody studies of Trichinella spiralis infections. J. Infect. Dis. 105: 97, 1959. CrossrefMedlineGoogle Scholar49. DAVISMOST WBH: Trichinosis. Amer. J. Med. 11: 639, 1951. CrossrefMedlineGoogle Scholar50. ROTHENBERG F: Treatment of trichinosis with cortisone. J. Med. Soc. New Jersey 48: 517, 1951. MedlineGoogle Scholar51. LUONGOREIDWEISS MADHWW: The effect of ACTH in trichinosis. New Engl. J. Med. 245: 757, 1951. CrossrefMedlineGoogle Scholar52. SEGARKASHTANMILLER LFHAPB: Trichinosis with myocarditis. New Engl. J. Med. 252: 397, 1955. CrossrefMedlineGoogle Scholar53. FORTIER JJ: ACTH and cortisone in trichinosis. Canad. Med. Ass. J. 72: 298, 1955. MedlineGoogle Scholar54. ROSEN E: Cortisone treatment of trichinosis. Amer. J. Med. Sci. 236: 16, 1952. CrossrefGoogle Scholar55. SOLOMONSELIGMON CB: Response of trichinosis to adrenocorticotropic hormone (ACTH) therapy. New York J. Med. 52: 1444, 1952. MedlineGoogle Scholar56. WERTHEIMCOHEN JMS: A case of trichinosis treated with cortisone. New York J. Med. 50: 1908, 1955. Google Scholar57. LEVINE J: A case of trichinosis with encephalitis. New York J. Med. 58: 578, 1958. MedlineGoogle Scholar58. MOVITTMACKENBROCKCLEMENT ERFGCE: Periarteritis nodosa. Stanford Med. Bull. 8: 59, 1959. Google Scholar59. DUNLAPWELLER GLCV: Pathogenesis of trichinous myocarditis. Proc. Soc. Exp. Biol. Med. 30: 1261, 1932. CrossrefGoogle Scholar60. SAPHIR O: Myocarditis. Arch. Path. 33: 88, 1942. Google Scholar61. STÄUBLI C: Trichinosis, J. F. Bergmann, Weisbaden, 1909, p. 295. Google Scholar62. WASSERMAN E: Trichinosis, observation on fifty sporadic cases. Conn. Med. J. 15: 965, 1951. MedlineGoogle Scholar63. SOLARY SD: An electrocardiographic study of one hundred fourteen consecutive cases of trichinosis. Amer. Heart J. 34: 230, 1947. CrossrefMedlineGoogle Scholar64. BEECHERAMIDON CHEL: Electrocardiographic changes in forty-four cases of trichinosis. Amer. Heart J. 16: 219, 1938. CrossrefGoogle Scholar65. REIMANN H: EKG, bei trichinose. Deut. Militärarzt 7: 448, 1942 (abstracted in Bull. War Med. 3: 337, 1942). Google Scholar66. OPPENHEIMWHIMSFRISCH JMCBAW: Clinical and laboratory observations on 256 cases of trichinosis. Bull. U. S. Army Med. Dept. 6: 581, 1946. MedlineGoogle Scholar67. PARRISIUSLAMPEROMERHONIGHAUS WGWL: Erfahrungen während einer Trichinose-epidemie. Deut. Militärarzt 7: 198, 1942 (abstracted in Bull. War Med. 3: 236, 1942). Google Scholar68. SPINK WW: Cardiovascular complications of trichinosis. Arch. Intern. Med. 56: 238, 1935. CrossrefGoogle Scholar69. MASTERJAFFE AMH: Electrocardiographic evidence of cardiac involvement in acute disease. Proc. Soc. Exp. Biol. Med. 31: 931, 1933. CrossrefGoogle Scholar70. FRIEDBERG CK: Diseases of the Heart, 2d Ed., W. B. Saunders Company, Philadelphia, 1956, p. 915. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Winston-Salem, North CarolinaFrom the Department of Medicine, Bowman Gray School of Medicine of Wake Forest College and the North Carolina Baptist Hospital, Winston-Salem, North Carolina.Requests for reprints should be addressed to Dean F. Gray, M.D., Infectious Disease Section, Jersey City Medical Center, Jersey City, New Jersey. 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MAYNARD, M.D., M.P.H.Case 36-1970 1 August 1962Volume 57, Issue 2_Part_1Page: 230-244KeywordsAutopsyDeath ratesElectrocardiographyEncephalitisHemorrhageHospital medicinePathogenesis Issue Published: 1 August 1962 PDF DownloadLoading ...