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Transepidermal Water Loss (TEWL) Reflects Skin Barrier Function of Dog

2008; Japanese Society of Veterinary Science; Volume: 70; Issue: 8 Linguagem: Inglês

10.1292/jvms.70.841

1347-7439

Kenichiro Shimada, Toru Yoshihara, Masahiko Yamamoto, Katsuhiko Konno, Yasuyuki Momoi, Koji Nishifuji, Toshiroh Iwasaki,

Ocular Surface and Contact Lens

The correlation between skin barrier function and transepidermal water loss (TEWL) was evaluated in dogs. Stratum corneum (SC) of 10 healthy dogs was removed by tape stripping (TS), which decreased the corneal layer to allow for permeation of fluorescent dye into skin. TEWL of damaged skin was measured with the closed-chamber-type TEWL analyzer, CC-01. The frequency of TS was directly related to the decrease of SC and the increased permeation of fluorescent dye, and TEWL increased with increasing impairment of skin barrier function. The results suggest that increased TEWL reflects impaired canine skin barrier function.