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Electrophysiology of GABAA and GABAB receptor subtypes

1988; Elsevier BV; Volume: 11; Issue: 3 Linguagem: Inglês

10.1016/0166-2236(88)90156-7

1878-108X

Joachim Bormann,

Nicotinic Acetylcholine Receptors Study

The participation of GABA receptors in the inhibitory transmission at mammalian central synapses was demonstrated experimentally two decades ago. Whilst the 'classical' action of GABA involves the opening of Cl− channels, pharmacologically distinct effects of GABA on cation channels were detected later. This led to the notion of GABAA and GABAB receptor subtypes. The GABAA receptor complex contains an integral Cl− ionophore, whereas GABAB receptors couple to Ca2+ and K+ channels via GTP-binding proteins. The physiological and pharmacological properties of GABAA and GABAB receptors will be discussed below in terms of ion channels that are activated by the two receptor subtypes.