Hop ( Humulus lupulus )-Derived Bitter Acids as Multipotent Bioactive Compounds
2009; American Chemical Society; Volume: 72; Issue: 6 Linguagem: Inglês
10.1021/np800740m
ISSN1520-6025
AutoresM. Van Cleemput, Ko Cattoor, Karolien De Bosscher, Guy Haegeman, Denis De Keukeleire, Arne Heyerick,
Tópico(s)Phytochemicals and Antioxidant Activities
ResumoHop acids, a family of bitter compounds derived from the hop plant (Humulus lupulus), have been reported to exert a wide range of effects, both in vitro and in vivo. They exhibit potential anticancer activity by inhibiting cell proliferation and angiogenesis, by inducing apoptosis, and by increasing the expression of cytochrome P450 detoxification enzymes. Furthermore, hop bitter acids are effective against inflammatory and metabolic disorders, which makes them challenging candidates for the treatment of diabetes mellitus, cardiovascular diseases, and metabolic syndrome. This review summarizes the current knowledge on hop bitter acids, including both phytochemical aspects, as well as the biological and pharmacological properties of these compounds.
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