Neuronal‐type nicotinic receptors in human neuroblastoma and small‐cell lung carcinoma cell lines
1992; Wiley; Volume: 312; Issue: 1 Linguagem: Inglês
10.1016/0014-5793(92)81411-e
ISSN1873-3468
AutoresPaola Tarroni, Francesca Rubboli, Bice Chini, Ruud Zwart, Marga Oortgiesen, Emanuele Sher, Francesco Clementi,
Tópico(s)Neuroblastoma Research and Treatments
ResumoA β subunit of the neuronal nicotinic receptor, sharing 88% homology with the rat β 4 subunit, has been cloned from a human neuroblastoma cell line. The gene encoding the human β 4 subunit is expressed in association with the α 3 gene in neuroblastoma and small‐cell lung carcinoma cell lines. Patch‐clamp experiments and radioligand binding assays confirm that these neuroendocrine tumor cell lines express functional neuronal nicotinic receptors. We suggest that these receptors might play a crucial role in the control of neurotransmitter and hormone secretion from neurosecretory human tumors.
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