Speed congenics: a classic technique in the fast lane (relatively speaking)
1997; Elsevier BV; Volume: 18; Issue: 10 Linguagem: Inglês
10.1016/s0167-5699(97)01126-2
ISSN1355-8242
AutoresEdward K. Wakeland, Laurence Morel, Karen Achey, Mary A. Yui, Jeff Longmate,
Tópico(s)Chromosomal and Genetic Variations
ResumoMarker-assisted selection protocol (MASP)-based strategies produce congenic strains with the target gene contained on clearly defined donor-derived genomic intervals in less than half the member of generations required by the classic protocol. Thus, the quality and speed of congenic strain construction are enhanced by this methodology. Here, Edward Wakeland and colleagues compare various MASP-based strategies and discuss their advantages with reference to immunological traits.
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