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CNS Siderosis and Dandy-Walker Variant After Neonatal Alloimmune Thrombocytopenia

2005; Elsevier BV; Volume: 32; Issue: 5 Linguagem: Inglês

10.1016/j.pediatrneurol.2004.11.008

1873-5150

José Ramón Castro Conde, Eduardo Doménech Martı́nez, Raúl Cabrera Rodríguez, Ana Lorena Rodríguez De Hoyos,

Blood groups and transfusion

This report presents a case of superficial siderosis of the central nervous system secondary to repeated intraventricular and subarachnoid bleeding of a newborn infant with neonatal alloimmune thrombocytopenia. In addition, this infant manifested Dandy-Walker variant. To date, the few known cases of superficial siderosis in neonates have not been associated with neonatal alloimmune thrombocytopenia or Dandy-Walker complex. We believe that repeated bleeding in the central nervous system from early fetal life, especially in the posterior fossa, may produce cerebellar atrophy as occurs in adults with superficial siderosis of the central nervous system.