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Artigo Revisado por pares
BIBTEX RIS

Diastereo‐ and Enantioselective Michael Addition Initiated Cyclizations to trans ‐Substituted Cyclopentanecarboxylates

1991; Wiley; Volume: 30; Issue: 12 Linguagem: Inglês

10.1002/anie.199116641

ISSN

1521-3773

Autores

Dieter Enders, Hermann J. Scherer, Gerhard Raabe,

Tópico(s)

Synthetic Organic Chemistry Methods

Resumo

Diastereomeric and enantiomeric excesses of greater than 95 % were achieved in the preparation of the cyclopentanecarboxylate 3 by asymmetric MIRC (Michael initiated ring closure) reactions of the hydrazones 1 with the unsaturated brominated ester 2. The de and ee values were determined by gas chromatography and in NMR experiments. RMe, nBu, iBu, Ph, p-BrC6H4.

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