Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms
2014; Elsevier BV; Volume: 123; Issue: 14 Linguagem: Inglês
10.1182/blood-2013-11-537167
ISSN1528-0020
AutoresPontus Lundberg, Axel Karow, Ronny Nienhold, Renate Looser, Hui Hao-Shen, Ina Nissen, Sabine Girsberger, Thomas Lehmann, Jakob Passweg, Martin Stern, Christian Beisel, Róbert Královics, Radek C. Skoda,
Tópico(s)Chronic Myeloid Leukemia Treatments
ResumoKey Points The total number of somatic mutations was inversely correlated with survival and risk of leukemic transformation in MPN. The great majority of somatic mutations were already present at MPN diagnosis, and very few new mutations were detected during follow-up.
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