Pharmaceutical evaluation of a new spacer device for delivery of metered-dose inhalers to infants and young children
1992; Elsevier BV; Volume: 23; Linguagem: Inglês
10.1016/0021-8502(92)90458-8
ISSN1879-1964
AutoresIan Ashurst, C.V. Ambrose, D.J. Russell,
Tópico(s)Inhalation and Respiratory Drug Delivery
ResumoA study has been carried out to evaluate the in-vitro performance of Ventolin1 metered-dose inhalers when used in conjunction with a new spacer device, named the Babyhaler1 device intended for use in babies and young children. This in-vitro assessment has been made using the Twin Impinger apparatus. A control experiment using no spacer device, and an experiment using an alternative paediatric spacer device, the Aerochamber2, has also been performed. The percent of dose delivered into Stage 2 of the Twin Impinger with the Babyhaler was 46% which was identical to the control experiment. The Aerochamber gave a Stage 2 deposition of only 12%. These differences were large enough to indicate a clinical difference between the two devices, indicating that the Babyhaler could be a useful device in young children.
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