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Selective Photolabeling near the Middle of Bilayers with a Photosensitive Transmembrane Probe

1993; Wiley; Volume: 32; Issue: 2 Linguagem: Inglês

10.1002/anie.199302591

1521-3773

Masakuni Yamamoto, William Warnock, Alain Milon, Yôichi Nakatani, Guy Ourisson,

Lipid Membrane Structure and Behavior

The efficient study of the inside of a membrane should no longer be a problem, thanks to the investigations described here. In vesicles from phospholipids, incorporated 1 (X  H,D) reacts upon irradiation with a selectivity up to 90% at positions ω −1 and ω −2 of the phospholipid chains, when, at the same time, cholesterol is a constituent of the membrane in normal bioconcentrations.