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The Location of Silicon Dioxide in Silicified Microcrystalline Cellulose

1999; Royal Pharmaceutical Society; Volume: 5; Issue: 6 Linguagem: Inglês

10.1211/146080899128734983

2047-9948

Stephen Edge, Ursula Potter, D. Fraser Steele, Mike Tobyn, Aiping Chen, John N. Staniforth,

biodegradable polymer synthesis and properties

Silicified microcrystalline cellulose (SMCC) is a novel tableting excipient which has been reported to exhibit improved binding capability as a material and in formulations. The material is also reported to show improved resistance to the deleterious effects of magnesium stearate compared with conventional microcrystalline cellulose. To understand the improvement in functionality of silicified microcrystalline cellulose the location of silicon dioxide in SMCC was investigated by studying particle surfaces and cross-sections using scanning electron microscopy together with electron probe micro-analysis. The results suggest that silicon dioxide is primarily located in the surface of SMCC. Some silicon dioxide was detected in the internal regions of some particles.