The effects of prostacyclin (PGI2) on tissues which detect prostaglandins (PG'S)
1977; Elsevier BV; Volume: 14; Issue: 4 Linguagem: Inglês
10.1016/0090-6980(77)90189-7
ISSN1878-416X
AutoresC. Omini, Salvador Moncada, John R. Vane,
Tópico(s)Eicosanoids and Hypertension Pharmacology
ResumoThe effects of prostacyclin (PGI2) and its stable metabolite 6-oxo-PGF1α on various bioassay tissues are compared with those of PGE2 and PGF2α, using the cascade superfusion method. On vascular smooth muscle, PGI2 caused relaxation of all tissues tested except the rabbit aorta. PGE2 relaxed rabbit coeliac and mesenteric artery but contracted bovine coronary artery and had no effect on rabbit aorta. 6-oxo-PGF1α was ineffective at the concentrations tested. On gastro-intestinal smooth muscle, PGI2 contracted strips of rat and hamster stomach and the chick rectum. It was less potent than PGE2 or PGF2α. None of these substances contracted that cat terminal ileum. 6-oxo-PGF1α was inactive on these tissues at the doses tested. PGI2 was less active than PGE2 or PGF2α in contracting guinea-pig trachea and rat uterus; 6-oxo-PGF1α was active only on the rat uterus. Thus, PGI2 can be distinguished from the other stable prostaglandins using the cascade method of superfusion.
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