Sleep deprivation decreases μ and δ opioid receptor binding in the rat limbic system
1991; Elsevier BV; Volume: 129; Issue: 2 Linguagem: Inglês
10.1016/0304-3940(91)90489-g
ISSN1872-7972
AutoresPaola Fadda, Alfonso Tortorella, W. Fratta,
Tópico(s)Adipose Tissue and Metabolism
ResumoSleep deprivation induced by the platform technique is considered to be a heavy stressful situation in rats. At the end of the sleep deprivation period (72 h) the rat displayed particular behavior characterized by wakefulness, a high degree of motor and exploratory activity, increased alertness and reactivity to environmental stimuli. Our previous results indicated that this behavior was antagonized by the administration of the opioid receptor antagonist naloxone and increased by opioid agonists. In this paper we show that concomitantly with this behavior, a decreased Bmax of μ and δ opioid receptors is present in the limbic system of these animals. These data suggest an active role of limbic μ and δ receptors in the generation of arousal and insomnia related to sleep deprivation induced stress.
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