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A genomic screen of Spanish multiple sclerosis patients reveals multiple loci associated with the disease

2003; Elsevier BV; Volume: 143; Issue: 1-2 Linguagem: Inglês

10.1016/j.jneuroim.2003.08.026

1872-8421

Robert Goertsches, Pablo Villoslada, Manuel Comabella, Xavier Montalbán, Arcadi Navarro, Emilio G. de la Concha, Rafael Arroyo, Adolfo López de Munaín, David Otaegui, Ricardo Palácios, Jordi Pérez‐Tur, Áslaug Jónasdóttir, Kjartan Benediktsson, Ragnheiður Fossdal, Stephen Sawcer, Efrosini Setakis, Alastair Compston,

T-cell and B-cell Immunology

Abstract In order to identify the genomic regions that might confer susceptibility to multiple sclerosis (MS) in the Spanish population, we have performed a genome-wide screen for association in patients with MS using pooled DNA from 200 clinical cases and 200 healthy controls. The pools were typed using 5546 microsatellites. The typing was repeated for the most promising 1269 markers after which 191 potentially associated markers were identified. Eleven of these markers map to the MHC region, and 14 to non-MHC regions identified in previous linkage screens. Our results provide support for the presence of multiple coding regions that contain MS susceptibility genes of small or moderate effect.