Hydroxylation of β-phenylethylamine in the rat
1974; Elsevier BV; Volume: 15; Issue: 9 Linguagem: Inglês
10.1016/0024-3205(74)90334-8
ISSN1879-0631
AutoresAlan A. Boulton, Lillian E. Dyck, David A. Durden,
Tópico(s)Amino Acid Enzymes and Metabolism
Resumoortho, meta and para Tyramine, as their dansyl derivatives, have been identified and quantitated by mass spectrometry in rat urine. After intraperitoneal injection of phenylethylamine labelled either with deuterium or tritium in the presence of pargyline, the amount of urinary tyramines excreted was 0.8% (para, 0.74%; meta, 0.12%; ortho, 0.008%) of the injected dose. The advantages of involving stable isotopes and mass spectrometry in metabolic studies of pharmacologically active compounds is discussed.
Referência(s)