Portal de Periódicos da CAPES

An Immunological Approach to Cancer

1968; American Medical Association; Volume: 206; Issue: 13 Linguagem: Inglês

10.1001/jama.1968.03150130060031

1538-3598

Chandler A. Stetson,

Monoclonal and Polyclonal Antibodies Research

In 1954, Professor Green put forth a conception of cancer which caused much discussion at the time and has served as a stimulus for a good deal of investigative work during subsequent years. This book is an account of this conception, now considerably amplified and extended, and an attempt to evaluate it in view of available experimental data. The basic concept advanced by Green is that "malignant cells are malignant because they have lost tissue-specific antigens and are no longer subject to tissue-homeostatic control mechanisms." The tissuespecific antigens are thought to be macromolecules on cell surfaces involved in direct cell-cell interactions or in interactions with humoral regulating agents such as the "chalones" of Bullough. Loss of these tissue-specific antigens, it is postulated, occurs as a consequence of any of several mechanisms, such as faulty genomic expression, interaction with autoantibodies, or alteration by chemical carcinogens. The cancer cell is one which