Systemic Lupus Erythematosus: Presence in Human Serum of an Unusual Acid-Labile Leukocyte Interferon
1982; American Association for the Advancement of Science; Volume: 216; Issue: 4544 Linguagem: Inglês
10.1126/science.6176024
ISSN1095-9203
AutoresOlivia T. Preble, Roberta Black, Robert M. Friedman, John H. Klippel, J Vilček,
Tópico(s)T-cell and B-cell Immunology
ResumoA previously undescribed species of human leukocyte, or alpha, interferon is present in the serum of many patients with systemic lupus erythematosus. It was shown to be α-interferon by neutralization with specific antiserums, affinity column chromatography, and antiviral activity on bovine cells. However, 23 of 30 interferon samples tested were inactivated by incubation at p H 2, a characteristic of human "immune," or gamma, interferon. Multiple samples of interferon from the same patient had similar biological properties, but samples from different patients were not all identical, suggesting that several variants of this species of human α-interferon may exist.
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